We know the terrible impact that MRSA can have on patients and recent research has identified a potential combination of drugs that can successfully combat MRSA. The research has focused on three drugs, Meropenem, Piperacillin and Tzobactum from a group of antibiotics called beta-lactams that when used alone are not able to kill MRSA but when used as a three drug strategy have proved effective against MRSA in laboratory conditions.
The study is published online Sept. 14 in the journal Nature Chemical Biology.
Working with collaborators in the microbiology laboratory in St. Louis, the research team tested and genetically analyzed 73 different variants of the MRSA microbe to represent a range of hospital-acquired and community-acquired forms of the pathogen. The researchers treated the various MRSA bugs with the three-drug combination and found that the treatments worked in every case.
Then, in experiments conducted by collaborators at the University of Notre Dame, the team found that the drug combination cured MRSA-infected mice and was as effective against the pathogen as one of the strongest antibiotics on the market.
The drugs, attack the cell wall of bacteria and work in a synergistic manner. The drugs didn’t produce resistance in MRSA bacteria which is valuable in not enhancing drug resistance.